The Welsh Terrier Club

The Welsh Terrier Club

Welsh Terrier Breed Health

To date the health of the Welsh Terrier has remained in a good state. However the club takes this matter very seriously and has appointed a breed health representative Alexandra Witmond.

 

If you have any questions or concerns regarding your pet’s health,  then please feel free to contact Alex, either by Tel. 01279 635130 or e-mail alex.tiltser@btinternet.com .

 

Primary Glaucoma/ Goniodysgenesis           by Alexandra Witmond     January 2018

Primary Glaucoma is a painful and blinding disease associated with intraocular pressure (high pressure inside the eye). It is an inherited condition and is sub divided into two types:
                              (1) primary open angle glaucoma and
                              (2) closed angle glaucoma.
In both forms, glaucoma results from reduced drainage of the fluid (aqueous humour) that is produced within the eye resulting in a build-up of intraocular pressure which in turn leads to pain and blindness. Welsh Terriers are among several breeds where closed angle glaucoma is significantly associated with an abnormality within the eye called Goniodysgenesis. In Welsh Terriers Goniodysgenesis is suspected of being inherited, and Welsh are on the Schedule B of the BVA/KC/ISDS eye scheme.  It is tested for by a technique called Gonioscopy.

Gonioscopy is generally performed without dilation of the pupil and an application of anaesthetic drops is applied to the eyes .The Vet Ophthalmologist will place a special lens on the surface of the cornea to enable the area of the eye to be examined.

Up to the end of 2017 the dog was either (a) Clinically Affected or (b) Clinically Unaffected. Now from 1st of January 2018 a new grading scheme has been introduced grading from 0 – 3:

  1. Grade 0 - clear 0%-1% - normal
  2. Grade 1 - clear / mildly affected, unlikely to develop primary Glaucoma. 1%-25%.

       Both suitable for breeding

  1. Grade 2 -low risk of developing primary glaucoma. 26%-75%

       Specific advice required for breeding.

  1. Grade 3 - severely affected, >75%. High risk of developing primary glaucoma

       Not recommended for breeding

At Manchester Championship Show this year, I took my two Welsh Terrier boys, Kevin and Ricky, along to the clinic, no appointment being necessary. Drops were put in and we were taken into a darkened room where the vet examined the eye. Not at all scary, both boys took it in their stride. Results are given straight away; pleased to say that both were clear. Paper work is needed, so do take along your KC registration papers as this will be correlated to the eye scheme.
For me, these tests are important especially as both my boys are used as stud dogs, so I felt that, as the Breed health co-coordinator, I’d better start the ball rolling. Both dogs are also PLL clear.

Examination for Goniodysgenesis can be done from 6 months old. The cost is between £40-60. Eye clinics are held around the country and at some Championship shows, and are listed in Our Dogs paper - or contact:

    • Canine Health Schemes, British Veterinary Association Tel: 02079806380
    • The Kennel Club: Tel 08444633980

     

     

     

    PAROXYSMAL DYSKINESIA – A MOVEMENT DISORDER: AN INVESTIGATION BY THE Royal Veterinary College.
    Visit our news page to read the full article

     

    MASTICATORY MUSCLE MYOSITIS (MMM)
    Masticatory Muscle Myositis is an autoimmune disorder in which antibodies attack the 2M fibres in the masticatory (chewing) muscle group.

    Although MMM can occur in any breed, it occurs more commonly in large breeds such as Golden Retrievers, Doberman Pinschers, German Shepherds, and Labrador Retrievers. Young Cavalier King Charles Spaniels may be severely affected.

    The condition occurs in males and females with an average age of onset of 3 years, though puppies as young as 4 months have been affected. Fortunately, if MMM is diagnosed early, dogs can be treated to increase the likelihood of a full recovery.

    Research of this disease at the University of California San Diego led to the development of a blood test in 2004 that detects the presence of 2M antibodies and accurately identifies affected dogs. The team identified type 2M fibres in the Masticatory muscle group and showed that antibodies against type 2M fibres are involved in the pathogenesis of MMM.

    MMM is an inflammatory myopathy. It is a unique myopathy or a muscle disease in which dogs commonly have jaw pain and inability to open the jaw.

    The genetic components of autoimmune disease are very complex. Although a great deal of research has been done to identify the causes of human autoimmune disease, much less research has been done in dogs. Genes play a role in increasing susceptibility to autoimmune disease but ENVIROMENTAL triggers initiate the onset of clinical signs.

    In dogs that are predisposed to autoimmune reactions, suspect triggers include viral and bacterial exposures, possibly vaccinations, hormones, stress, allergens, medications, and environmental toxins. It is NOT purely a genetic disease - hormonal, environmental and other unknown factors come into play .

    RECOGNIZING SIGNS OF MMM
    Owners who recognize these signs of MMM in their dogs should seek veterinary care:

    1) Inability to open the jaw.
    2) Jaw pain.
    3) Swelling or atrophy of the jaw muscle.
    4) Difficulty in eating or drinking.
    5) Reluctance to play with toys.
    6) Sunken or protruding eyes.
    If the disease is diagnosed early and a dog is treated appropriately the prognosis is good for
    dogs with MMM.

    Regarding breeding recommendations; MMM is not considered to be a high priority disease to target reduction. This is due to the genetic and environmental complexities, the low incidence of the disease, the overall good outcome with appropriate therapy and, importantly, the concern for maintaining as much genetic diversity in the breed.

     

    PRIMARY LENS LUXATION

    Since March 2012 a genetic condition has come to light that affects Welsh Terriers. It’s called Primary Lens Luxation (PLL).

    This condition is caused by an inherited mutation in a gene which is required for the healthy construction of the lens fibres. PLL is an inherited eye disease which can lead to blindness. In affected dogs, the tiny fibres which hold the lens break down and the lens can fall out of position which may cause glaucoma and blindness. This is a late onset condition – an affected dog would develop signs of PLL between 4 to 8 years of age.

    Thankfully, there is a test for identification of the DNA mutation which has only been available since 2009. This test is useful for those breeders, or pet owners who want to breed, to identify the status of their breeding stock, so that they are not breeding from affected animals as affected dogs should not be bred from.

    There can be three results–
    • CLEAR – free of the PLL mutation
    • CARRIER – has one copy of the mutation
    • AFFECTED – has two copies of the mutation


    As we have a small gene pool in Welsh Terriers, CARRIERS can be used for breeding but only to CLEAR animals, then the pups should be tested; CARRIERS X CLEAR = 50% CARRIER / 50% CLEAR.

    The Kennel club announced that, from 29th August 2013, testing results which qualify for the Kennel Club's DNA Screening Schemes will be accepted from Animal DNA Diagnostics Ltd who carry out this PLL screening, and will be posted on the Kennel Club website. Future results will routinely be forwarded without the need for owners to contact the Kennel Club.

    This test is not yet a requirement of the Kennel Club, but a lot of breeders having been doing the test to their stock on a voluntary basis.

    Anyone who would like further information, please email me at alex.tiltser@btinternet.com, or if you would like to get the kit to do this simple swab test, then email Dr June Swinbourne at info@animaldnadiagnostics.co.uk quoting Breed296 to get a 5% discount.

     

    October 2017 - Update
    We have now had feedback from Animal DNA Diagnostics:  in the years that this service has been available, 129 Welsh Terriers have been tested – of which 87 (68%) are clear, 38 (29%) are carriers and just 4 (3%) are affected.

    More information , covering breeding advice, on the Animal Health Trust’s website -  
    http://www.aht.org.uk/cms-display/genetics_pll.html